Observation of arterial blood pressure of the primate AAP-Bio-A-1 Quarterly progress report, 10 Jul. - 9 Oct. 1968

Circuits, components, and implant site evaluations for arterial blood pressure analyses on primate

Blood pressure, sensor development, atrial size measurement, and implant materials Progress report, 10 Apr. - 9 Jul. 1969

Research in medical science, University of Southern Californi

Crystallization of biological macromolecules in a reduced gravity environment

A battery of micro techniques were developed which allow the screening of a large number of conditions using only a small amount of the macromolecule. The need to develop methodologies for growing large crystals required for neutron diffraction studies is discussed

Role of atrial receptors in the control of sodium excretion

Responses of an innervated and a contralateral chronically denervated kidney to mild positive pressure breathing are compared for saline volume expansions in chloralose anesthetized dogs. It is shown that mild pressure breathing significantly reduces sodium excretion, urine flow, free water clearance, and PAH clearance. After 20 minutes of positive pressure breathing, both kidney responses are identical suggesting the release of natriuretic hormone which reduces renal function in addition to the demonstrated change in renal nerve activity. Increase of the left atrial pressure through balloon obstruction of the mitral orifice increases urine flow, sodium excretion and PAH clearance; inflation of the balloon and positive pressure breathing again depresses renal function. Preliminary evidence indicates that receptors in the right atrium are more severely affected by pressure breathing than those in the left atrium

Monitoring cardiovascular function in the primate under prolonged weightlessness

Monitoring cardiovascular function in primates under prolonged weightlessnes

An overview of the VRS virtual platform

This paper provides an overview of the development of the virtual platform within the European Commission funded VRShips-ROPAX (VRS) project. This project is a major collaboration of approximately 40 industrial, regulatory, consultancy and academic partners with the objective of producing two novel platforms. A physical platform will be designed and produced representing a scale model of a novel ROPAX vessel with the following criteria: 2000 passengers; 400 cabins; 2000 nautical mile range, and a service speed of 38 knots. The aim of the virtual platform is to demonstrate that vessels may be designed to meet these criteria, which was not previously possible using individual tools and conventional design approaches. To achieve this objective requires the integration of design and simulation tools representing concept, embodiment, detail, production, and operation life-phases into the virtual platform, to enable distributed design activity to be undertaken. The main objectives for the development of the virtual platform are described, followed by the discussion of the techniques chosen to address the objectives, and finally a description of a use-case for the platform. Whilst the focus of the VRS virtual platform was to facilitate the design of ROPAX vessels, the components within the platform are entirely generic and may be applied to the distributed design of any type of vessel, or other complex made-to-order products

Ship product modelling

This paper is a fundamental review of ship product modeling techniques with a focus on determining the state of the art, to identify any shortcomings and propose future directions. The review addresses ship product data representations, product modeling techniques and integration issues, and life phase issues. The most significant development has been the construction of the ship Standard for the Exchange of Product Data (STEP) application protocols. However, difficulty has been observed with respect to the general uptake of the standards, in particular with the application to legacy systems, often resulting in embellishments to the standards and limiting the ability to further exchange the product data. The EXPRESS modeling language is increasingly being superseded by the extensible mark-up language (XML) as a method to map the STEP data, due to its wider support throughout the information technology industry and its more obvious structure and hierarchy. The associated XML files are, however, larger than those produced using the EXPRESS language and make further demands on the already considerable storage required for the ship product model. Seamless integration between legacy applications appears to be difficult to achieve using the current technologies, which often rely on manual interaction for the translation of files. The paper concludes with a discussion of future directions that aim to either solve or alleviate these issues

A low power blood flow transmitter. Transmission of cardiovascular response to weightlessness Progress report, 1 Mar. - 31 May 1970

Low power blood flow transmitter to determine cardiovascular response to weightlessnes

Erythroderma with circulating atypical T-cells, likely Sézary syndrome

The erythrodermic patient is often challenging and requires careful evaluation. Work-up should include an extensive and careful medication history, histological and laboratory testing, and if necessary, molecular studies for the evaluation of underlying malignancy. Herein, we present an erythrodermic patient with repeated biopsies demonstrating a spongiotic process who was found to have circulating atypical T-cells concerning for an underlying erythrodermic T-cell leukemia, most closely related to Sézary syndrome